For over 60 years, metformin has been the standard treatment for managing blood sugar levels in patients with type 2 diabetes. Traditionally, it has been understood that metformin primarily lowers blood glucose by reducing glucose output in the liver. However, recent research from Baylor College of Medicine has unveiled a significant new understanding of how this drug operates within the brain.

On March 25, 2026, researchers published their findings in Science Advances, revealing that metformin also affects a specific brain pathway. This discovery challenges the long-held belief that its effects were limited to the liver and gut.

The study highlights that metformin works by turning off the protein Rap1 in the ventromedial hypothalamus (VMH), a critical brain region involved in regulating metabolism. Mice lacking Rap1 did not show improvement in diabetes-like conditions when treated with metformin, underscoring the importance of this protein in the drug’s efficacy.

Dr. Makoto Fukuda, a lead researcher, stated, “This discovery changes how we think about metformin.” He emphasized that while the liver and intestines require high concentrations of the drug to respond, the brain reacts to much lower levels of metformin.

Furthermore, the activation of SF1 neurons in the VMH by metformin suggests their crucial role in the drug’s action. This finding indicates that metformin’s effects on the brain could lead to innovative diabetes treatments that directly target this newly identified pathway.

In addition to its blood sugar-lowering effects, metformin is known for its other health benefits, including slowing brain aging. A notable study found that women taking metformin had a 30% lower risk of dying before age 90 compared to those taking sulfonylurea, further establishing its potential as a gerotherapeutic.

As research continues, the implications of these findings are significant. They not only enhance our understanding of metformin but also open the door to developing new diabetes treatments that could improve patient outcomes by targeting brain mechanisms.

With the ongoing exploration of metformin’s multifaceted effects, the medical community is eager to see how this knowledge will shape future diabetes therapies. The integration of brain health into diabetes treatment could revolutionize the approach to managing this chronic condition.

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“I’m in denial! I’m just in total denial. I don’t even want to talk about it. Being 80 is just unfathomable to me,” expressed Candice Bergen as she approaches her milestone birthday in May 2026. The five-time Emmy winner’s candid remarks highlight the complexities of aging, especially as she reflects on her father’s passing at the age of 75.

Bergen’s perspective on life and aging is shaped by her experiences, and she emphasizes the importance of gratitude, stating, “It’s a gift. It’s not always the purest gift, but it’s important to be grateful for it.” This sentiment resonates as she continues to navigate her career in the entertainment industry.

In a notable recent project, Bergen guest-stars as Derek’s mother, Constance, in the Apple TV+ series Shrinking. Her character has a contentious relationship with Liz, adding depth to the show’s narrative. Bergen’s involvement comes at a time when the series is gaining traction, particularly following the emergency bypass surgery undergone by Derek Bishop, played by Christa Miller.

Miller remarked on the dynamic between the characters, stating, “Working with Candice Bergen and having her be the mother-in-law, the scenes were crackling.” This collaboration showcases Bergen’s enduring talent and ability to captivate audiences.

Meanwhile, the fashion world is also witnessing significant changes. Chloe Malle, who has worked at Vogue for 14 years, has recently been appointed as the new US Head of Editorial Content. Her promotion follows the departure of Anna Wintour, who stepped down after 37 years as Editor-in-Chief.

Malle’s ascent in the fashion industry underscores the evolving landscape of media and editorial leadership, as she brings her extensive experience to the forefront. “She’s been at Vogue for 14 years, so she didn’t just talk her way into it … She worked up to it,” Bergen noted, highlighting the meritocratic nature of the industry.

As Bergen prepares for her 80th birthday, her reflections on aging and her ongoing contributions to television and film continue to inspire both fans and colleagues alike. The upcoming months will likely see her further engage with audiences through her role in Shrinking and beyond.

Details remain unconfirmed regarding any future projects or appearances, but Bergen’s legacy in the entertainment industry remains firmly established.

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A recent study published in Nature Medicine has brought attention to the potential effects of daily multivitamin intake on biological aging. The research indicates that taking a daily multivitamin may slow markers of biological aging, a finding that could have significant implications for health as people age.

The study involved 958 healthy participants with an average chronological age of 70. Over the course of two years, those who took multivitamins showed about four months less biological aging compared to those who did not. This was measured using five epigenetic clocks, which are tools that assess biological age based on genetic markers.

Importantly, the research excluded participants with major chronic illnesses, cancer, or cardiovascular conditions, ensuring that the results were focused on a healthy demographic. The study was part of the larger COSMOS trial, which was funded by Mars and the US National Institutes of Health, with Pfizer providing support through supplement donations.

Despite the promising results, experts urge caution in interpreting these findings. Professor Luigi Fontana noted that the observed change in biological aging was “very, very small,” and emphasized that individuals who maintain a healthy diet typically do not require supplements. Furthermore, the study’s findings cannot be generalized to other populations, as the participants were predominantly white and around the age of 70.

There is also no evidence that multivitamins would reduce disease risk or increase survival rates. The research found that cocoa extract, another component of the study, did not have any effect on the five epigenetic clocks tested, indicating that the benefits observed were specifically linked to multivitamin intake.

Experts like Howard Sesso have stated, “We are not yet in a position to recommend a daily multivitamin for all older adults.” This highlights the need for further research to determine the broader applicability of these findings. Additionally, the specific reasons why multivitamins may impact health markers remain unknown, leaving room for further investigation.

As the allure of slowing down the aging process continues to captivate many, the study serves as a reminder that while multivitamins may offer some benefits, they are not a substitute for a balanced diet. Details remain unconfirmed regarding the applicability of these results to different ages and ethnicities, and ongoing research will be essential to clarify these uncertainties.

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A recent study suggests that a daily multivitamin may slow biological aging by about four months over a two-year period. This finding raises important questions about the role of multivitamins in promoting healthier aging and their potential benefits for individuals.

Study Overview

The research, published in Nature Medicine, analyzed DNA methylation data from blood samples of 958 participants, who had an average chronological age of 70. Participants were randomized into four groups: one group received a multivitamin and cocoa extract, another received cocoa extract and a placebo, a third group received a multivitamin and a placebo, and the final group received two placebos. The study found statistically significant slowing in two epigenetic clocks that are predictive of mortality.

Key Findings

One of the most notable findings from the study is that those who were biologically older than their actual age benefited the most from multivitamin supplementation. This suggests that multivitamins might play a role in mitigating the effects of biological aging, particularly for older adults who may be experiencing accelerated aging processes.

Expert Insights

Howard Sesso, a key researcher involved in the study, expressed enthusiasm about the results, stating, “It was exciting to see the benefits of a multivitamin linked with markers of biological aging.” He further noted, “A lot of people take a multivitamin without necessarily knowing any benefits from taking it, so the more we can learn about its potential health benefits, the better.”

Funding and Research Context

The study was funded by the National Institutes of Health, highlighting the importance of government support in advancing research on health and aging. The findings open the door to learning more about accessible, safe interventions that could contribute to healthier, higher-quality aging.

Uncertainties and Future Directions

Despite the promising results, details remain unconfirmed regarding the clinical relevance of the findings. It is still unclear who specifically benefits from multivitamin supplementation, and further research is needed to determine the long-term effects of multivitamins on biological aging.

As the study suggests a potential link between multivitamin use and slowed biological aging, it underscores the need for continued investigation into the health benefits of multivitamins. With no known risks associated with taking a multivitamin in the context of the study, the findings may encourage more individuals to consider multivitamin supplementation as part of their health regimen.

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The question of whether a daily multivitamin can influence biological aging has gained traction following a recent study that suggests it may indeed have a positive effect. Specifically, the study indicates that daily multivitamin supplementation could slow biological aging by about four months over a two-year period.

Study Overview and Findings

The research, published in Nature Medicine, analyzed DNA methylation data from blood samples of 958 participants, who had an average chronological age of 70. Participants were randomized into four groups: one receiving a multivitamin and cocoa extract, another receiving cocoa extract and a placebo, a third receiving a multivitamin and a placebo, and the last group receiving two placebos. This design allowed researchers to isolate the effects of the multivitamin.

Notably, the study found statistically significant slowing in two epigenetic clocks that are predictive of mortality. These epigenetic clocks estimate biological aging based on changes in DNA methylation, providing a scientific basis for assessing the impact of interventions like multivitamins on aging.

Who Benefits Most?

Interestingly, the study suggests that those who were biologically older than their actual age benefited the most from multivitamin supplementation. This finding raises important questions about the potential for multivitamins to serve as a safe and accessible intervention for promoting healthier aging.

Expert Opinions

Howard Sesso, one of the researchers involved in the study, expressed enthusiasm about the findings, stating, “It was exciting to see the benefits of a multivitamin linked with markers of biological aging.” He also noted, “A lot of people take a multivitamin without necessarily knowing any benefits from taking it, so the more we can learn about its potential health benefits, the better.” However, he cautioned that it is critical to determine the clinical relevance of these findings.

Safety and Future Research

Importantly, Sesso indicated that there are no known risks associated with taking a multivitamin in the context of their two large clinical trials. This safety profile, combined with the potential benefits, makes multivitamins an appealing option for many individuals seeking to improve their health as they age.

What Lies Ahead?

While the study opens the door to learning more about accessible, safe interventions that contribute to healthier, higher-quality aging, details remain unconfirmed regarding the clinical relevance of the findings. Additionally, it is still not known who specifically benefits the most from multivitamin supplementation.

As research in this area continues, the implications of these findings could reshape our understanding of dietary supplements and their role in aging. Further studies will be necessary to clarify the long-term effects of multivitamins on biological aging and to identify the populations that might gain the most from their use.

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